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| 产品描述 |
| NCB-0846 is an orally available TNIK inhibitor with an IC50 of 21nM.IC50 & Target: IC50: 21nM.
In Vitro: NCB-0846 has anti-Wnt activity. NCB-0846 binds to TNIK in an inactive conformation, and this binding mode seems to be essential for Wnt inhibition. NCB-0846 shows inhibitory activity against TNIK with an IC50of 21nM. NCB-0846 also inhibits FLT3, JAK3, PDGFRα, TRKA, CDK2/CycA2, and HGK. NCB-0846 induces faster migration of TCF4 phosphorylated by TNIK within a concentration range of 0.1-0.3μM and completely inhibits the phosphorylation of TCF4 at a concentration of 3μM. NCB-0846 inhibits HCT116 cell growth and shows much higher (～20-fold) inhibitory activity against colony formation by the same cells in soft agar.
In Vivo: NCB-0846 suppresses the growth of tumors established by inoculating HCT116 cells into immunodeficient mice. The expression of Wnt-target genes (AXIN2, MYC and CCND1) in xenografts is reduced following the administration of NCB-0846. NCB-0846 induces an increase in the sub-G1 cell population. Cleavage of poly (ADP-ribose) polymerase 1 indicates the induction of apoptosis. |
| 化学结构 |
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| 基本信息 |
产品编号:XM432
产品名称:NCB0846
别名:NCB 0846; NCB0846
CAS#:1792999-26-8
分子量:375.42
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| 物化性质 |
外观: 白色或类白色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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