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| 产品描述 |
| TAK-580, also known as MLN2480, BIIB024, and AMG 2112819, is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf. |
| 化学结构 |
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| 化学名称 |
| (R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide |
| SMILES Code |
| O=C(C1=CN=C([C@H](NC(C2=NC=NC(N)=C2Cl)=O)C)S1)NC3=NC=C(Cl)C(C(F)(F)F)=C3 |
| 基本信息 |
产品编号:XM409
产品名称:TAK-580 (MLN2480)
别名:TAK-580; TAK 580; TAK580; MLN 2480; MLN-2480; MLN2480; BIIB024, BIIB 024, BIIB-024; AMG 2112819; AMG2112819; AMG-2112819.
CAS#:1096708-71-2
分子式:C17H12Cl2F3N7O2S
精确分子量:505.01023
分子量:506.29
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| 物化性质 |
外观: 白色或类白色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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