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| 产品描述 |
| Rabusertib, also known as LY2603618, is a n inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk2 is overexpressed by a variety of cancer cell types. |
| 化学结构 |
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| 化学名称 |
| (S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea. |
| SMILES Code |
| CC1=C(Br)C=C(C(OC[C@@H]2CNCCO2)=C1)NC(NC3=NC=C(N=C3)C) |
| 基本信息 |
产品编号:XM367
产品名称:Rabusertib (LY2603618)
别名:LY2603618; LY 2603618; LY-2603618; Rabusertib
CAS#:911222-45-2
分子式:C18H22BrN5O3
精确分子量:435.0906
分子量:436.3
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| 物化性质 |
外观: 白色或类白色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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