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| 产品描述 |
| ND-646 is-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo. Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth. When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC. ND-646 had enhanced efficacy when combined with carboplatin, a common component of chemotherapeutic regimens used to treat human NSCLC. |
| 化学结构 |
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| 化学名称 |
| 2-(1-((R)-2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4,4a,7a-tetrahydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanamide |
| SMILES Code |
| COC1=CC=CC=C1[C@H](CN2C(N(C(C)(C)C(N)=O)C(C3C2SC(C4=NC=CO4)=C3C)=O)=O)OC5CCOCC5 |
| 基本信息 |
产品编号:XM348
产品名称:ND-646
别名:ND-646; ND 646; ND646.
CAS#:1434639-57-2
分子式:C28H34N4O7S
精确分子量:570.2148
分子量:570.661
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| 物化性质 |
外观: 白色或类白色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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