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| 产品描述 |
| Semaxanib, also known as SU5416, is a quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. |
| 化学结构 |
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| 化学名称 |
| (Z)-3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one |
| SMILES Code |
| O=C1NC2=C(C=CC=C2)/C1=C/C3=C(C)C=C(C)N3 |
| 基本信息 |
产品编号:XM322
产品名称:Semaxanib
别名:SU5416; SU-5416; SU 5416; Sugen 5416; semoxind; Semaxanib
CAS#:204005-46-9
分子式:C15H14N2O
精确分子量:238.11061
分子量:238.28
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| 物化性质 |
外观: 淡黄色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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