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| 产品描述 |
| IDH889 is a potent and selective inhibitors of IDH1. IDH899 shows IDH (R132H) IC50 = 20 nM; Cell 2-HG IC50 = 14 nM. IDH889 demonstrates significantly improved plasma exposure in mice vs IDH662 (AUC 3.6 μM•h, Cmax 1.7 μM at 10 mg/kg; AUC 55.5 μM•h, Cmax 14.2 μM at 100 mg/kg). IDH889 also has excellent permeability and no efflux in the Caco-2 and human MDR1-MDCK cell lines, supporting the hypothesis that potent inhibition of mutant IDH1 function by binding at the allosteric binding site is compatible with brain penetration. |
| 化学结构 |
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| 化学名称 |
| (S)-3-(2-(((S)-1-(5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl)ethyl)amino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one |
| SMILES Code |
| CC1=C(F)C=CC(C2=CN=C([C@@H](NC3=NC(N4[C@@H](C(C)C)COC4=O)=CC=N3)C)N=C2)=C1 |
| 基本信息 |
产品编号:XM319
产品名称:IDH889
别名:IDH889; IDH-889; IDH 889.
CAS#:1429179-07-6
分子式:C23H25FN6O2
精确分子量:436.2023
分子量:436.4914
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| 物化性质 |
外观: 白色或类白色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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