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| 产品描述 |
| GS-9901 is a potent, orally active and highly selective inhibitor of PI3Kδ (PI3Kdelta IC50 = 1.0nM, HWB delta EC50 = 1.5 nM; CLpr hHep = 0.05 L/h/kg.). GS-9901 displays an excellent pharmacokinetic profile and is efficacious in a rodent model of rheumatoid arthritis. GS-9901 demonstrates efficacy in a rat model of arthritis and is predicted to be suitable for q.d. dosing in humans. The favorable in vitro and in vivo attributes of GS-9901 resulted in its selection as a development candidate. |
| 化学结构 |
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| 化学名称 |
| (S)-2,4-diamino-6-(((5-chloro-8-fluoro-4-oxo-3-(pyridin-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile |
| SMILES Code |
| N#CC1=C(N)N=C(N)N=C1N[C@@H](C2CC2)C(N3C4=CC=CN=C4)=NC5=C(C(Cl)=CC=C5F)C3=O |
| 基本信息 |
产品编号:XM316
产品名称:GS-9901
别名:GS-9901; GS 9901; GS9901.
CAS#:1640247-87-5
分子式:C22H17ClFN9O
精确分子量:477.1229
分子量:477.8884
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| 物化性质 |
Related CAS #: 1640247-87-5 (GS-9901) 1640248-45-8 (GS-9901 R-isomer)
外观: 白色或类白色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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