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| 产品描述 |
| AZD7451, also known as AZ12607092, is a tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. AZD7451 binds to TRK, thereby preventing the neurotrophin-TRK interaction and subsequent TRK activation. This may eventually result in an inhibition of tumor cell proliferation in TRK-expressing tumor cells. TRK, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth, invasion and survival. |
| 化学结构 |
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| 化学名称 |
| (S)-N-(1-(5-fluoropyrimidin-2-yl)ethyl)-3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-amine |
| SMILES Code |
| C[C@H](NC1=CC=C2C(N(C3=NNC(OC(C)C)=C3)C=N2)=N1)C4=NC=C(F)C=N4 |
| 基本信息 |
产品编号:XM296
产品名称:AZD7451
别名:AZD-7451; AZD7451; AZD 7451; AZ12607092; AZ 12607092; AZ-12607092.
CAS#:1079274-94-4
分子式:C18H19FN8O
精确分子量:382.1666
分子量:382.4034
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| 物化性质 |
外观: 白色或类白色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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