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| 产品描述 |
| Idelalisib, also known as CAL-101, is a PI3K-delta inhibitor with potential immunomodulating and antineoplastic activities. CAL-101 inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. CAL-101 has [EC(50)] = 8nM. TFA approved this drug on July 23, 2014. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). |
| 化学结构 |
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| 化学名称 |
| (S)-2-(1-((9H-purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one |
| SMILES Code |
| O=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4N=CNC4=NC=N3)CC)=NC5=C1C(F)=CC=C5 |
| 基本信息 |
产品编号:XM255
产品名称:Idelalisib (CAL-101)
别名:CAL101; CAL 101; CAL-101; GS1101; GS 1101; GS-1101, Idelalisib.
CAS#:870281-82-6
分子式:C22H18FN7O
精确分子量:415.1557
分子量:415.423
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| 物化性质 |
外观: 白色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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