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| 产品描述 |
| Epacadostat, also known as INCB024360 or INCB24360, is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. INCB024360 targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, INCB024360 increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs). |
| 化学结构 |
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| 化学名称 |
| (Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-((2-(sulfamoylamino)ethyl)amino)-1,2,5-oxadiazole-3-carboximidamide |
| SMILES Code |
| O=S(NCCNC1=NON=C1/C(NC2=CC=C(F)C(Br)=C2)=N/O)(N)=O |
| 基本信息 |
产品编号:XM021
产品名称:Epacadostat (INCB024360)
别名:INCB024360; INCB 024360; INCB-024360; INCB24360; INCB-24360; INCB 24360; Epacadostat
CAS#:1204669-58-8 (or 1204669-37-3)
分子式:C11H13BrFN7O4S
精确分子量:436.99171
分子量:438.23
纯度:>98%
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| 物化性质 |
外观: 类白色固体
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3 年-20℃ 固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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