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| 产品描述 |
| FIIN-2 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-2 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-2 also binds in the DFG-out mode despite lacking a functional group necessary to occupy the pocket vacated upon the DFG-out flip. |
| 化学结构 |
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| 化学名称 |
| N-(4-((3-(3,5-dimethoxyphenyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide |
| SMILES Code |
| O=C(NC1=CC=C(C=C1)CN2C(N(CC3=CN=C(N=C32)NC4=CC=C(C=C4)N5CCN(CC5)C)C6=CC(OC)=CC(OC)=C6)=O)C=C |
| 基本信息 |
产品编号:XM208
产品名称:FIIN-2
别名:FIIN2; FIIN 2; FIIN-2.
CAS#:1633044-56-0
分子式:C35H38N8O4
精确分子量:634.3016
分子量:634.72742
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| 物化性质 |
外观: 固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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