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| 产品描述 |
| Filgotinib, also known as GLPG0634, is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn's disease. It is considered a promising agent as it inhibits JAK1 selectively. Filgotinib displayed a selectivity of 30-fold for JAK1- over JAK2-dependent signaling. GLPG0634 dose-dependently inhibited Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro. |
| 化学结构 |
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| 化学名称 |
| N-(5-(4-((1,1-dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide. |
| SMILES Code |
| O=C(C1CC1)NC2=NN3C(C4=CC=C(CN5CCS(CC5)(=O)=O)C=C4)=CC=CC3=N2. |
| 基本信息 |
产品编号:XM017
产品名称:Filgotinib (GLPG0634)
别名:GLPG0634; GLPG 0634; GLPG-0634. Filgotinib; PubChemSID 163643231
CAS#:1206161-97-8
分子式:C21H23N5O3S
精确分子量:425.15216
分子量:425.5
纯度:>98%
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| 物化性质 |
外观: 类白色固体
纯度: >98% 运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3 年-20℃ 固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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