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| 产品描述 |
| LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function. |
| 化学结构 |
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| 化学名称 |
| 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |
| SMILES Code |
| O=C1C=C(N2CCOCC2)OC3=C(C4=CC=CC=C4)C=CC=C13 |
| 基本信息 |
产品编号:XM158
产品名称:LY294002
别名:LY294002; LY-294002; LY 294002
CAS#:154447-36-6
分子式:C19H17NO3
精确分子量:307.12084
分子量:307.34
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| 物化性质 |
外观: 固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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