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| 产品描述 |
| Prexasertib, also know LY2606368, is a n inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. Upon administration, LY2606368 selectively binds to chk1, thereby preventing activity of chk1 and abrogating the repair of damaged DNA. This may lead to an accumulation of damaged DNA and may promote genomic instability and apoptosis. LY2606368 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapeutic agents. |
| 化学结构 |
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| 化学名称 |
| 5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile |
| SMILES Code |
| N#CC1=NC=C(NC2=NNC(C3=C(OC)C=CC=C3OCCCN)=C2)N=C1 |
| 基本信息 |
产品编号:XM133
产品名称:Prexasertib free base
别名:LY2606368; LY 2606368; LY-2606368; Prexasertib free base
CAS#:1234015-52-1 (free base)
分子式:C18H19N7O2
精确分子量:365.16002
分子量:365.38916
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| 物化性质 |
Related CAS #:1234015-54-3 (2HCl) 1234015-55-4(mesylate) 1234015-52-1 (free base) 1234015-57-6(mesylate hydrate)
外观: 固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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